Recent Publications

2024

Loss of neuronal Imp induces seizure behavior through Syndecan function. Roy PR and Link N. bioRxiv 2024.11.21.624719; doi: https://doi.org/10.1101/2024.11.21.624719.

Molecular functions of ANKLE2 and its implications in human disease. Fishburn AT, Florio CJ, Link N, Shah PS. Dis Model Mech 2024 Apr1;17(4): dmm050554. https://doi.org/10.1242/dmm.0050554.

A Zika virus protein expression screen in Drosophila to investigate targeted host pathways during development. Link N, Harnish JM, Hull B, Gibson S, Dietze M, Mgbike UE, Medina-Balcazar S, Shah PS, Yamamoto S. Dis Model Mech. 2024 Feb 1;17(2):dmm050297. https://doi.org/10.1242/dmm.050297.

A novel adipose loss-of-function mutant in Drosophila. Losurdo NA, Bibo A, Bedke J, Link N. Fly (Austin). 2024 May 13;18(1):2352938. https://doi.org/10.1080/19336934.2024.2352938.

2023

A novel adipose loss-of-function mutant in Drosophila
Losurdo NA, Bibo A, Bedke J, Link N. bioRxiv. 2023 Aug 19;. doi: https://doi.org/10.1101/2023.08.18.553914.

2022

Thomas AX, Link N, Robak LA, Demmler-Harrison G, Pao EC, Squire AE, Michels S, Cohen JS, Comi A, Prontera P, Verrotti di Pianella A, Di Cara G, Garavelli L, Caraffi SG, Fusco C, Zuntini R, Parks KC, Sherr EH, Hashem MO, Maddirevula S, Alkuraya FS, Contractar IAF, Neil JE, Walsh CA, Bellen HJ, Chao HT, Clark RD, Mirzaa GM. Ann Clin Transl Neurol. 2022 Aug;9(8):1276-1288. doi: 10.1002/acn3.51629. Epub 2022 Jul 24. PMID: 35871307

2021

Drosophila as a Model for Infectious Diseases

Harnish MJ, Link N, Yamamoto S. Int. J. Mol. Sci. 2021 Mar 8;22(5):2724. doi.org/10.3390/ijms22052724. Epub 2021 Mar 8.PMID: 33800390

2020

Using Drosophila to drive the diagnosis and understand the mechanisms of rare human diseases

Link N, Bellen HJ.Development. 2020 Sept 28;147:dev191411. doi:10.1242/dev.191411. Epub 2020 Sept 28.PMID: 32988995

2019

Mutations in ANKLE2, a ZIKA Virus Target, Disrupt an Asymmetric Cell Division Pathway in Drosophila Neuroblasts to Cause Microcephaly.

Link N, Chung H, Jolly A, Withers M, Tepe B, Arenkiel BR, Shah PS, Krogan NJ, Aydin H, Geckinli BB, Tos T, Isikay S, Tuysuz B, Mochida GH, Thomas AX, Clark RD, Mirzaa GM, Lupski JR, Bellen HJ.Dev Cell. 2019 Dec 16;51(6):713-729.e6. doi: 10.1016/j.devcel.2019.10.009. Epub 2019 Nov 14.PMID: 31735666

Drosophila p53 directs nonapoptotic programs in postmitotic tissue.

Kurtz P, Jones AE, Tiwari B, Link N, Wylie A, Tracy C, Krämer H, Abrams JM.Mol Biol Cell. 2019 May 15;30(11):1339-1351. doi: 10.1091/mbc.E18-12-0791. Epub 2019 Mar 20.PMID: 30892991

2018

Comparative Flavivirus-Host Protein Interaction Mapping Reveals Mechanisms of Dengue and Zika Virus Pathogenesis.

Shah PS, Link N, Jang GM, Sharp PP, Zhu T, Swaney DL, Johnson JR, Von Dollen J, Ramage HR, Satkamp L, Newton B, Hüttenhain R, Petit MJ, Baum T, Everitt A, Laufman O, Tassetto M, Shales M, Stevenson E, Iglesias GN, Shokat L, Tripathi S, Balasubramaniam V, Webb LG, Aguirre S, Willsey AJ, Garcia-Sastre A, Pollard KS, Cherry S, Gamarnik AV, Marazzi I, Taunton J, Fernandez-Sesma A, Bellen HJ, Andino R, Krogan NJ.Cell. 2018 Dec 13;175(7):1931-1945.e18. doi: 10.1016/j.cell.2018.11.028.PMID: 30550790

2017

Developmental Expression of 4-Repeat-Tau Induces Neuronal Aneuploidy in Drosophila Tauopathy Models.

Malmanche N, Dourlen P, Gistelinck M, Demiautte F, Link N, Dupont C, Vanden Broeck L, Werkmeister E, Amouyel P, Bongiovanni A, Bauderlique H, Moechars D, Royou A, Bellen HJ, Lafont F, Callaerts P, Lambert JC, Dermaut B.Sci Rep. 2017 Jan 23;7:40764. doi: 10.1038/srep40764.PMID: 28112163

2015

Hid arbitrates collective cell death in the Drosophila wing.

Garcia-Hughes G, Link N, Ghosh AB, Abrams JM.Mech Dev. 2015 Nov;138 Pt 3:349-55. doi: 10.1016/j.mod.2015.07.008. Epub 2015 Jul 29.PMID: 26226435

Towards automatic image analysis and assessment of the multicellular apoptosis process.

Ziraldo R, Link N, Abrams J, Ma L.IET Image Process. 2015 May;9(5):424-433. doi: 10.1049/iet-ipr.2014.0531. Epub 2015 Apr 30.PMID: 26500693

Analysis of p53 transactivation domain mutants reveals Acad11 as a metabolic target important for p53 pro-survival function.

Jiang D, LaGory EL, Kenzelmann Brož D, Bieging KT, Brady CA, Link N, Abrams JM, Giaccia AJ, Attardi LD.Cell Rep. 2015 Feb 24;10(7):1096-109. doi: 10.1016/j.celrep.2015.01.043. Epub 2015 Feb 19.PMID: 25704813

2014

A drosophila genetic resource of mutants to study mechanisms underlying human genetic diseases.

Yamamoto S, Jaiswal M, Charng WL, Gambin T, Karaca E, Mirzaa G, Wiszniewski W, Sandoval H, Haelterman NA, Xiong B, Zhang K, Bayat V, David G, Li T, Chen K, Gala U, Harel T, Pehlivan D, Penney S, Vissers LELM, de Ligt J, Jhangiani SN, Xie Y, Tsang SH, Parman Y, Sivaci M, Battaloglu E, Muzny D, Wan YW, Liu Z, Lin-Moore AT, Clark RD, Curry CJ, Link N, Schulze KL, Boerwinkle E, Dobyns WB, Allikmets R, Gibbs RA, Chen R, Lupski JR, Wangler MF, Bellen HJ.Cell. 2014 Sep 25;159(1):200-214. doi: 10.1016/j.cell.2014.09.002.PMID: 25259927

DNA loops specify p53 network responses.

Link N, Abrams JM.Cell Cycle. 2014;13(11):1659. doi: 10.4161/cc.29149. Epub 2014 May 8.PMID: 24810566

Automatic image analysis of multicellular apoptosis process.

Ziraldo R, Link N, Abrams J, Ma L.Conf Proc IEEE Eng Med Biol Soc. 2014;2014:4643-6. doi: 10.1109/EMBC.2014.6944659.PMID: 25571027

2013

A p53 enhancer region regulates target genes through chromatin conformations in cis and in trans.

Link N, Kurtz P, O’Neal M, Garcia-Hughes G, Abrams JM.Genes Dev. 2013 Nov 15;27(22):2433-8. doi: 10.1101/gad.225565.113.PMID: 24240233

2009

Genome-wide silencing in Drosophila captures conserved apoptotic effectors.

Chew SK, Chen P, Link N, Galindo KA, Pogue K, Abrams JM.Nature. 2009 Jul 2;460(7251):123-7. doi: 10.1038/nature08087. Epub 2009 May 31.PMID: 19483676

2007

A collective form of cell death requires homeodomain interacting protein kinase.

Link N, Chen P, Lu WJ, Pogue K, Chuong A, Mata M, Checketts J, Abrams JM.J Cell Biol. 2007 Aug 13;178(4):567-74. doi: 10.1083/jcb.200702125. Epub 2007 Aug 6.PMID: 17682052